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A complete of 3 % of Lively compound is excreted in urine as unchanged Energetic material. Tapentadol is On top of that metabolised to N-desmethyl tapentadol (13 %) by CYP2C9 and CYP2C19 and to hydroxy tapentadol (two %) by CYP2D6, that are even further metabolised by conjugation. As a result, active compound metabolism mediated by cytochrome P450